Rezende, T.P.; Corrêa, J.O.A.; Aarestrup, B.J.V.; Aarestrup, F.M.; de Sousa, O.V.; da Silva Filho, A.A. Protective Effects of Baccharis dracunculifolia Leaves Extract against Carbon Tetrachloride- and Acetaminophen-Induced Hepatotoxicity in Experimental Animals. Molecules 2014, 19, 9257-9272.
Abstract
In this work we investigated the in vivo protective effects of Baccharis dracunculifolia leaves extract (BdE) against carbon tetrachloride (CCl4)- and acetaminophen (APAP)-induced hepatotoxicity. Total phenolic content, total flavonoid content, antioxidant DPPH radical scavenging activity, and HPLC analysis were performed. Our results showed that pretreatment with BdE significantly reduced the damage caused by CCl4 and APAP on the serum markers of hepatic injury, AST, ALT, and ALP. Results were confirmed by histopathological analysis. Phytochemical analysis, performed by HPLC, showed that BdE was rich in p-coumaric acid derivatives, caffeoylquinic acids and flavonoids. BdE also showed DPPH antioxidant activity (EC50 of 15.75 ± 0.43 μg/mL), and high total phenolic (142.90 ± 0.77 mg GAE/g) and flavonoid (51.47 ± 0.60 mg RE/g) contents. This study indicated that B. dracunculifolia leaves extract has relevant in vivo hepatoprotective properties.
Conclusions
Our results demonstrated, for the first time, that the oral treatment with BdE is effective for prevention of both CCl4- and APAP-induced liver damage, similarly to Brazilian propolis [12,13]. Then, this study demonstrated that the B. dracunculifolia leaves extract has relevant in vivo hepatoprotective properties, supporting its traditional use. However, more detailed in vivo studies are required to establish the safety and clinical relevance of B. dracunculifolia leaves extract.
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