Dias, C.; Aires, A.; Saavedra, M.J. Antimicrobial Activity of Isothiocyanates from Cruciferous Plants against Methicillin-Resistant Staphylococcus aureus (MRSA). Int. J. Mol. Sci. 2014, 15, 19552-19561.
Abstract
Purified isothiocyanates from cruciferous plants (Brassicacea, Syn. Cruciferae) plants were evaluated against 15 isolates of methicillin-resistant S. aureus isolated from diabetic foot-ulcer patients aiming the study of the potential usage of allyl-isothiocyanate, benzyl-isothiocyanate and 2-phenylethyl-isothiocyanate against this important bacteria. Disc diffusion and minimum inhibitory concentration methods were used to access the antimicrobial activity. The index (Ia) and rate (Ra) of the antibacterial activity for each compound were calculated. The results showed a highly dose-dependent compound and chemical structure antibacterial effectiveness. The results showed a strong relation between the chemical structure of isothiocyanates and its antibacterial effectiveness. The benzyl-isothiocyanate was the most effective with a minimum inhibitory concentration varying between 2.9 and 110 µg·mL−1 with an antibacterial activity rate up to 87%. Moreover, their antibacterial activity was mainly bactericidal. This study provides scientific evidence that isothiocyanates have an interesting biological value and must be considered as an important tool to be used against MRSA.
Conclusions
Based on our results, we can conclude that cruciferous plants such as mustards, cress, watercress and turnips, can play an important role as natural source of BITC and PEITC, both with strong antimicrobial activity against MRSA. Thus, these specific compounds can be used in pharmacological formulations, alone or in combination with traditional antibiotics against MRSA. Synergistic studies with antibiotics or other natural compounds with recognized antibacterial activity should be studied experimentally in order to obtain more information, including toxicity.
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