Capsaicin - Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside

Edited by Gyula Mozsik, Omar M. E. Abdel- Salam and Koji Takeuchi, ISBN 978-953-51-1631-8, 320 pages, Publisher: InTech, Chapters published July 16, 2014 under CC BY 3.0 license
DOI: 10.5772/57289

The capsaicin, a component of paprika, has been used in the culinary practice of every day nutritional practice. This agent is known to cause a variety of actions in the body through activating capsaicin-sensitive afferent neurons. A recently launched book entitled, Capsaicin-Sensitive Neural Afferentation and the Gastrointestinal Tract: from Bench to Bedside, is attractive for several reasons. First, Prof. Mozsik, a chief editor of this book, is known internationally as an expert in capsaicin pharmacology. Since he has worked for many years as a head of internal medicine, taking care of patients with various GI diseases, he is able to make a correct interpretation of various findings obtained in basic researches to clinical events. Second, although there are many articles about capsaicin, they mostly deal with basic research and finding but do not include much about clinical finding. Third, this book encompassed review articles written by internationally accepted scientists leading the field of capsaicin research, who highlighted the current state of knowledge on pharmacology, physiology and clinical phathophysiology of capsaicin-sensitive afferent neurons, and discussed directions for future research. Overall, this book is for people who are interested in the capsaicin action in body.

Chapter 1 Discovery and Mechanism of Gastroprotective Action of Capsaicinby János Szolcsányi

Chapter 2 Pharmacobotanical analysis and regulatory qualification of Capsicum fruits and Capsicum extracts. A survey.by Monika Kuzma, Tibor Past, Gyula Mozsik and Pal Perjesi

Chapter 3 Allyl Isothiocyanate, a Pungent Ingredient of Wasabi and Mustard Oil, Impairs Gastric Paracellular Barrier in Primary Cultures from the Rat Stomach via TRPA1-Independent Pathwayby Kimihito Tashima, Misako Kabashima, Kenjiro Matsumoto, Shingo Yano, Susan J. Hagen and Syunji Horie

Chapter 4 Cooperative Effects of Neuronal Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase on Gastric Hyperemic Response to Intragastric Capsaicinby Syunji Horie, Masaki Raimura, Kenjiro Matsumoto, Takao Namiki, Katsutoshi Terasawa, John V. Priestley and Kimihito Tashima

Chapter 5 Modulation of Capsaicin-Induced Gastric Protection by Endogenous Prostaglandins through EP2/IP Receptorsby Koji Takeuchi

Chapter 6 Mechanism of Capsaicin-Stimulated Gastric HCO3- Secretion – Comparison with Mucosal Acidificationby Koji Takeuchi and Eitaro Aihara

Chapter 7 The Role of Capsaicin-Sensitive Afferent Nerves in Gastric Mucosal Protection Initiated Centrally or Peripherally under Experimental Conditionsby Klara Gyires

Chapter 8 Stable Gastric PentadecapeptideBPC 157, Somatosensory Neurons and Their Protection and Therapeutic Extensions — A Surveyby Predrag Sikiric

Chapter 9 Lafutidine Protects the NSAID-Induced Small Intestinal Lesions Mediated by Capsaicin-Sensitive Afferent Neuronsby Kikuko Amagase and Koji Takeuchi

Chapter 10 Capsaicin-Sensitive Afferent Nerves and the Human Gastrointestinal Tractby Gyula Mózsik, András Dömötör, József Czimmer, Imre L. Szabó and János Szolcsányi

Chapter 11 Capsaicin is a New Gastrointestinal Mucosal Protecting Drug Candidate in Humans — Pharmaceutical Development and Production Based on Clinical Pharmacologyby Gyula Mózsik, Tibor Past, Tamás Habon, Zsuzsanna Keszthelyi, Pál Perjési, Mónika Kuzma, Barbara Sándor, János Szolcsányi, M.E. Abdel-Salam Omar and Mária Szalai