Vecchi Brumatti, L.; Marcuzzi, A.; Tricarico, P.M.; Zanin, V.; Girardelli, M.; Bianco, A.M. Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments. Molecules 2014, 19, 21127-21153.
Abstract
Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn’s disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-κB) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC.
Conclusions
Curcumin is a natural compound that reduces the development of chronic experimental colitis and alleviates the inflammatory response whose precise modes of action is still unclear, and it seems likely that its molecular targets differ according to cell and disease system. Several studies have demonstrated the promising role of curcumin as a novel therapy for children and adults with IBD.
To date a precise understanding of the effective dose, safe regimental therapy, and mechanism of action for the use of curcumin in the treatment of IBD is unknown, but there is abundant evidence proving its effects on the NF-κB pathway and p38 MAPK in the intestinal mucosa.
The key role played by curcumin in the diet and its implications for the quality of life of IBD
patients should be studied because preliminary data obtained in clinical trials are very encouraging.
The pleiotropic role of curcumin in IBD pathogenesis and range severity of phenotype is very remarkable.
We conclude that large-scale, double-blind trials need to be conducted to establish the role of curcumin in the treatment of IBD. The parameters crucial to be included in the study are disease onset, age of patients, pharmacological assumptions and diet interaction, administration with respect to the inflammation phase (acute or in regression). In case of nanoformulations, clinical trials are also required to establish not only the efficacy, but also the safety in case of repeated use. In conclusion we think that it is necessary to deepen if, how and how much curcumin is useful for preventing the recurrence of IBD by modifying the patient’s diet in remission periods and/or for decreasing the mucosal inflammation in the acute phase.
Link:
Nenhum comentário:
Postar um comentário